Comparative evaluation of intranasal midazolam-ketamine, dexmedetomidine-ketamine, midazolam-fentanyl, and dexmedetomidine-fentanyl combinations for procedural sedation and analgesia in pediatric dental patients: a randomized controlled trial
Abhilasha Agarwal, Afroz Alam Ansari, Rajendra Nath, Rakesh Kumar Chak, Rajeev Kumar Singh, Richa Khanna, Prem Raj Singh,
소속 상세정보
( Abhilasha Agarwal ) -
( Afroz Alam Ansari ) -
( Rajendra Nath ) -
( Rakesh Kumar Chak ) -
( Rajeev Kumar Singh ) -
( Richa Khanna ) - King George Medical University Faculty of Dental Sciences Department of Pediatric and Preventive Dentistry
( Prem Raj Singh ) -
Abstract
Background: In order to assess the effectiveness of various analgesio-sedative combinations for pain relief and sedation in pediatric dental patients, a thorough evaluation of clinical studies and patient outcomes is necessary.
Methods: A total of 128 healthy, uncooperative pediatric dental patients were randomly allocated to receive one of the four combinations of drugs via the intranasal (IN) route: Group I received midazolam-ketamine (MK), Group II received dexmedetomidine-ketamine (DK), Group III received midazolam-fentanyl (MF), and Group IV received dexmedetomidine-fentanyl (DF) in a parallel-arm study design. The efficacy and safety of the combinations were evaluated using different parameters.
Results: The onset of sedation was significantly faster in the DF group than in the DK, MF, and MK groups (P < 0.001). The depth of sedation was significantly higher in the DK and DF groups than in the MK and MF groups (P < 0.01). DK and DF produced significant intra- and postoperative analgesia when compared with combinations of MK and MF. No significant adverse events were observed for any of the combinations.
Conclusions: The DK and DF groups showed potential as analgesio-sedatives in view of their anxiolytic and analgesic effects.
키워드
Analgesio-sedation; Dental anxiety; Dexmedetomidine; Fentanyl; Ketamine; Midazolam
원문 및 링크아웃 정보
등재저널 정보